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Article

HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.

International journal of molecular sciences - 20 Feb 2014

Zhao Wenhui, Zhao Jinfeng, Hou Miaomiao, Wang Yue, Zhang Yang, Zhao Xin, Zhang Ce, Guo Dawei

Abstract excerpt

SIRT1 is a pleiotropic protein that plays critical and multifunctional roles in metabolism, senescence, longevity, stress-responses, and cancer, and has become an important therapeutic target across a range of diseases. Recent research demonstrated that SIRT1 pre-mRNA undergoes alternative splicing to produce different isoforms, such as SIRT1 full-length and SIRT1-∆Exon8 variants. Previous studies revealed these...

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Source

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Identifiers

PMID: 24566137
DOI: 10.3390/ijms15022946
PMCID: PMC3958892

Genes

SIRT1
TIA1
TIAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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