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Article

SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation.

The Journal of steroid biochemistry and molecular biology - 1 Sept 2017

Sabir Marya S, Khan Zainab, Hu Chengcheng, Galligan Michael A, Dussik Christopher M, Mallick Sanchita, Stone Angelika Dampf, Batie Shane F, Jacobs Elizabeth T, Whitfield G Kerr, Haussler Mark R, Heck Michael C, Jurutka Peter W

Abstract excerpt

The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Herein, it is revealed for the first time that VDR is post-translationally acetylated, and that VDR immunoprecipitated from human embryonic kidney (HEK293) cells displays a dramatic...

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Identifiers

PMID: 28636886
DOI: 10.1016/j.jsbmb.2017.06.010
PMCID: PMC5584940

Genes

VDR
SIRT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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