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Article

Human T Lymphocyte Genetic Modification with Naked DNA

1 Jan 2000

Abstract excerpt

Endowing T lymphocytes with novel functional attributes by genetic modification is under development for a broad range of clinical cellular immunotherapy applications. To circumvent many of the limitations associated with viral vector systems, a plasmid-based electroporation system that reliably generates G418-resistant primary human T lymphocyte clones was developed. TCR alpha/beta+ CD4+CD8-, and CD4-CD8+ T...

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Identifiers

PMID: 10933911
DOI: 10.1006/mthe.1999.0012

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