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Article

Human gene targeting by viral vectors.

Nature genetics - 1 Apr 1998

Russell D W, Hirata R K

Abstract excerpt

Stable transduction of mammalian cells typically involves random integration of viral vectors by non-homologous recombination. Here we report that vectors based on adeno-associated virus (AAV) can efficiently modify homologous human chromosomal target sequences. Both integrated neomycin phosphotr...

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Topics

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Share to Genes
Share to Genes, Viral
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Recombinant Proteins

Share to Recombination, Genetic

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Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 9537413
DOI: 10.1038/ng0498-325
PMCID: PMC3010411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9537413-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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