Article
Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.
Cell - 22 Feb 1991
Cleves A E, McGee T P, Whitters E A, Champion K M, Aitken J R, Dowhan W, Goebl M, Bankaitis V A
Abstract excerpt
SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function. We now report that the SEC14p localizes to the yeast Golgi and that the SEC14p requirement can be specifically and efficiently bypassed by mutations in any one of at least six genes. One of these suppressor genes was the structural gene for yeast...
Topics
- Carrier Proteins
- Cloning, Molecular
- Cytidine Diphosphate Choline
- Genes, Fungal
- Genes, Suppressor
- Genotype
- Golgi Apparatus
- Membrane Proteins
- Phosphatidylcholines
- Phosphatidylinositols