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Article

SPO14 separation-of-function mutations define unique roles for phospholipase D in secretion and cellular differentiation in Saccharomyces cerevisiae.

Genetics - 1 Aug 2001

Rudge S A, Pettitt T R, Zhou C, Wakelam M J, Engebrecht J A

Abstract excerpt

In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid. SPO14 is essential for cellular differentiation during meiosis and is required for Golgi function when the normal secretory apparatus is perturbed (Sec14-independent secretion). We isolated specific alleles of SPO14 that support Sec14-independent...

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Identifiers

PMID: 11514437
DOI: 10.1093/genetics/158.4.1431
PMCID: PMC1461740

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Source receipt: pubmed, retrieved 7 Sept 2026.

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