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Article

A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast.

The Journal of biological chemistry - 3 Jul 1998

Sreenivas A, Patton-Vogt J L, Bruno V, Griac P, Henry S A

Abstract excerpt

The SEC14 gene encodes a phosphatidylinositol/phosphatidylcholine transfer protein essential for secretion and growth in yeast (1). Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis suppress the sec14 growth defect (2), permitting sec14(ts) cki1, sec14(ts) cct1, and sec14(ts) cpt1 strains to grow at the sec14(ts) restrictive temperature. Previously, we reported that...

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Source

Identifiers

PMID: 9642212
DOI: 10.1074/jbc.273.27.16635

Genes

PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast.PMID 9642212Read ↗

Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.Semantic proximity Read ↗

SPO14 separation-of-function mutations define unique roles for phospholipase D in secretion and cellular differentiation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.Semantic proximity Read ↗

An essential role for a phospholipid transfer protein in yeast Golgi function.Semantic proximity Read ↗

The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity.Semantic proximity Read ↗

SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.Semantic proximity Read ↗

Characterization and regulation of yeast Ca2+-dependent phosphatidylethanolamine-phospholipase D activity.Semantic proximity Read ↗

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes.Semantic proximity Read ↗

Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects.Semantic proximity Read ↗

Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of phospholipid biosynthesis by phosphatidylinositol transfer protein Sec14p and its homologues. A critical role for phosphatidic acid.Semantic proximity Read ↗

Identification of a novel, Ca(2+)-dependent phospholipase D with preference for phosphatidylserine and phosphatidylethanolamine in Saccharomyces cerevisiae.Semantic proximity Read ↗

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