Article
Cessation of growth to prevent cell death due to inhibition of phosphatidylcholine synthesis is impaired at 37 degrees C in Saccharomyces cerevisiae.
The Journal of biological chemistry - 15 Nov 2002
Howe Alicia G, Zaremberg Vanina, McMaster Christopher R
Abstract excerpt
Phosphatidylcholine is the most abundant phospholipid in eukaryotic cells, comprising 50% of total cellular phospholipid, and thus plays a major role in cellular and organellar biogenesis. In this study, we have used both nutritional deprivation as well as a conditional temperature sensitive allele of PCT1 (CTP:phosphocholine cytidylyltransferase) coupled with an inactivated phosphatidylethanolamine methylation...
Topics
- Alleles
- Carboxypeptidases
- Cathepsin A
- Cell Death
- Cell Division
- Cell Membrane
- Cell Nucleus
- Cell Survival
- Cytoplasm
- DNA
- Lipid Metabolism
- Microscopy, Fluorescence
- Models, Biological
- Phosphatidylcholines
- Protein Binding
- Saccharomyces cerevisiae
- Temperature
- Time Factors