Article
Low mannose-binding lectin levels and MBL2 gene polymorphisms associate with Chlamydia pneumoniae antibodies.
Innate immunity - 1 Feb 2011
Rantala Aino, Lajunen Taina, Juvonen Raija, Bloigu Aini, Paldanius Mika, Silvennoinen-Kassinen Sylvi, Peitso Ari, Vainio Olli, Leinonen Maija, Saikku Pekka
Abstract excerpt
OBJECTIVE: Mannose-binding lectin (MBL) has been shown to inhibit infection of host cells by Chlamydia pneumoniae in vitro. We studied if MBL levels and MBL2 polymorphisms associate with the presence of C. pneumoniae antibodies in vivo. MATERIALS AND METHODS: Single nucleotide polymorphisms (SNPs) of the MBL2 gene (promoter alleles H/L, X/Y and P/Q; and exon 1 variant alleles B, C and D and wild-type allele A)...
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