Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Dec 2014

Darton T C, Jack D L, Johnson M, Borrow R, Guiver M, Kaczmarski E B, Turner M W, Klein N J, Read R C

Abstract excerpt

Mannose binding lectin (MBL2) is a soluble pattern recognition receptor that is key to generating innate immune responses to invasive infection, including against the cardinal Gram-negative bacterium Neisseria meningitidis. Individuals homozygous or heterozygous for any of three variant alleles of MBL2 (O/O or A/O genotypes) have deficient concentrations of MBL2 in circulating blood, but previous studies linking...

Topics

Join the communities discussing this publication.

Bacteremia
Bacterial Load
Blood
Disease Susceptibility
Mannose-Binding Lectin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Meningococcal Infections

Metabolism, Inborn Errors

Neisseria meningitidis

Source

Identifiers

PMID: 24977653
DOI: 10.1111/1469-0691.12745

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children.PMID 24977653Read ↗

Genetic susceptibility to invasive meningococcal disease: MBL2 structural polymorphisms revisited in a large case-control study and a systematic review.Semantic proximity Read ↗

Mannose-binding lectin gene, MBL2, polymorphisms are not associated with susceptibility to invasive pneumococcal disease in children.Semantic proximity Read ↗

Impact of mannose-binding lectin on susceptibility to infectious diseases.Semantic proximity Read ↗

Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients.Semantic proximity Read ↗

Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants.Semantic proximity Read ↗

Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection.Semantic proximity Read ↗

Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.Semantic proximity Read ↗

Genotypes coding for mannose-binding lectin deficiency correlated with cryptococcal meningitis in HIV-uninfected Chinese patients.Semantic proximity Read ↗

Detection of three single nucleotide polymorphisms in the gene encoding mannose-binding lectin in a single pyrosequencing reaction.Semantic proximity Read ↗

Mannose-binding lectin genotype influences frequency and duration of infectious complications in children with malignancy.Semantic proximity Read ↗

Mannose-binding lectin genotype is associated with respiratory disease in young children: A multicenter cohort study.Semantic proximity Read ↗

Characterization of mannose-binding lectin (MBL) variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.