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Article

An epistasis effect of functional variants on the BDNF and DRD2 genes modulates gray matter volume of the anterior cingulate cortex in healthy humans.

Neuropsychologia - 1 Mar 2010

Montag Christian, Weber Bernd, Jentgens Eva, Elger Christian, Reuter Martin

Abstract excerpt

Recent evidence suggests that mesolimbic dopaminergic pathways are regulated by the brain derived neurotrophic factor (BDNF). The present study shows that the prominent single nucleotide polymorphisms (SNPs) BDNF Val66Met and DRD2 Taq Ia/ANKK1 exert an epistasis effect on the anterior cingulate cortex (ACC) in 161 healthy Caucasian participants. Carriers with at least one 66Met allele (Val66Met and Met66Met) of...

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Source

Identifiers

PMID: 19961866
DOI: 10.1016/j.neuropsychologia.2009.11.027

Genes

BDNF
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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