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Article

Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2010

Montag Christian, Markett Sebastian, Basten Ulrike, Stelzel Christine, Fiebach Christian, Canli Turhan, Reuter Martin

Abstract excerpt

Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1...

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Source

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Identifiers

PMID: 20410875
DOI: 10.1038/npp.2010.55
PMCID: PMC3055626

Genes

BDNF
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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