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Article

Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex.

Human molecular genetics - 1 Mar 2010

Traherne James A, Martin Maureen, Ward Rosemary, Ohashi Maki, Pellett Fawnda, Gladman Dafna, Middleton Derek, Carrington Mary, Trowsdale John

Abstract excerpt

The fine-scale structure of the majority of copy number variation (CNV) regions remains unknown. The killer immunoglobulin receptor (KIR) gene complex exhibits significant CNV. The evolutionary plasticity of the KIRs and their broad biomedical relevance makes it important to understand how these immune receptors evolve. In this paper, we describe haplotype re-arrangement creating novel loci at the KIR complex. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19959527
DOI: 10.1093/hmg/ddp538
PMCID: PMC2816608

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