Article
Recombinant structures expand and contract inter and intragenic diversification at the KIR locus.
BMC genomics - 8 Feb 2013
Pyo Chul-Woo, Wang Ruihan, Vu Quyen, Cereb Nezih, Yang Soo Young, Duh Fuh-Mei, Wolinsky Steven, Martin Maureen P, Carrington Mary, Geraghty Daniel E
Abstract excerpt
BACKGROUND: The human KIR genes are arranged in at least six major gene-content haplotypes, all of which are combinations of four centromeric and two telomeric motifs. Several less frequent or minor haplotypes also exist, including insertions, deletions, and hybridization of KIR genes derived from the major haplotypes. These haplotype structures and their concomitant linkage disequilibrium among KIR genes suggest...
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