Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women.

doi:10.1158/1078-0432.CCR-08-1829

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Article

Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2009

Chen Xiaojun, Han Suping, Wang Sumin, Zhou Xiaoyi, Zhang Mingfeng, Dong Jing, Shi Xiaoyan, Qian Nianfeng, Wang Xinru, Wei Qingyi, Shen Hongbing, Hu Zhibin

Abstract excerpt

PURPOSE: Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Th1 responses and thus participates in the carcinogenesis of human papillomavirus-related cervical cancer. We hypothesized that potentially functional polymorphisms in IL12A and IL12B may individually and jointly contribute to cervical cancer risk. EXPERIMENTAL DESIGN: We genotyped IL12A rs568408 [3' untranslated...

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PMID: 19118071
DOI: 10.1158/1078-0432.CCR-08-1829

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