Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.

Emerging microbes & infections - 1 Dec 2021

Hu Jin, Tang Liudi, Cheng Junjun, Zhou Tianlun, Li Yuhuan, Chang Jinhong, Zhao Qiong, Guo Ju-Tao

Abstract excerpt

Upon infection of hepatocyte, Hepatitis B virus (HBV) genomic DNA in nucleocapsid is transported into the nucleus and converted into a covalently closed circular (ccc) DNA to serve as the template for transcription of viral RNAs. Viral DNA in the cytoplasmic progeny nucleocapsid is another resource to fuel cccDNA amplification. Apparently, nucleocapsid disassembly, or viral genomic DNA uncoating, is an essential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to DNA, Circular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exodeoxyribonucleases

Share to Hep G2 Cells

Share to Hepatocytes

Share to Nucleocapsid

Share to Nucleotidyltransferases

Share to Phosphoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33870849
DOI: 10.1080/22221751.2021.1919034
PMCID: PMC8812769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.PMID 33870849Read ↗

Viral DNA-Dependent Induction of Innate Immune Response to Hepatitis B Virus in Immortalized Mouse HepatocytesSemantic proximity Read ↗

Hepatitis B Virus Covalently Closed Circular DNA Formation in Immortalized Mouse Hepatocytes Associated with Nucleocapsid DestabilizationSemantic proximity Read ↗

Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA FormationSemantic proximity Read ↗

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?Semantic proximity Read ↗

The Role of cccDNA in HBV MaintenanceSemantic proximity Read ↗

Alteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation.Semantic proximity Read ↗

Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA FormationSemantic proximity Read ↗

New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA FormationSemantic proximity Read ↗

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis BSemantic proximity Read ↗

Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNASemantic proximity Read ↗

DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNASemantic proximity Read ↗

Mechanism for CCC DNA synthesis in hepadnaviruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.