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Virus-derived circular RNAs populate hepatitis C virus–infected cells

6 Feb 2024

Abstract excerpt

It is known that pre-mRNAs in eukaryotic cells can be processed to circular RNAs by a backsplicing mechanism. Circular RNAs have great stability and can sequester proteins or small RNAs to exert functions on cellular pathways. Because viruses often exploit host pathways, we explored whether the RNA genome of the cytoplasmic hepatitis C virus is processed to yield virus-derived circRNAs (vcircRNAs). Computational...

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PMID: 38319965
DOI: 10.1073/pnas.2313002121

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