A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC).

doi:10.1016/j.lungcan.2014.03.008

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A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC).

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2014

Azad Abul Kalam, Qiu Xin, Boyd Kevin, Kuang Qin, Emami Marjan, Perera Nicole, Palepu Prakruthi, Patel Devalben, Chen Zhuo, Cheng Dangxiao, Feld Ronald, Leighl Natasha B, Shepherd Frances A, Tsao Ming-Sound, Xu Wei, Liu Geoffrey, Cuffe Sinead

Abstract excerpt

INTRODUCTION: Lung cancer is a leading cause of cancer-related mortality in North America. In addition to tobacco smoking, inherited genetic factors can also influence the development of lung cancer. These genetic factors may lead to biologically distinct subsets of cancers that have different outcomes. We evaluated whether genetic sequence variants (GSVs) associated with lung cancer risk are associated with...

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PMID: 24679952
DOI: 10.1016/j.lungcan.2014.03.008

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TERT

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A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC).PMID 24679952Read ↗

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Genetic variant rs401681 at 5p15.33 modifies susceptibility to lung cancer but not esophageal squamous cell carcinoma.Semantic proximity Read ↗

Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population.Semantic proximity Read ↗

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.Semantic proximity Read ↗

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Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.Semantic proximity Read ↗

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