Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas.

International journal of cancer - 20 Feb 1991

Carbone G, Borrello M G, Molla A, Rizzetti M G, Pierotti M A, Della Porta G, Parmiani G

Abstract excerpt

The DNA of 22 fibrosarcomas, newly induced in BALB/c mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridization performed on the DNA of the 22 sarcomas revealed 5 cases of K-ras mutation at codon 12, 3 at...

Topics

Animals
Antigens, Neoplasm
Base Sequence
Female
Fibrosarcoma
Gene Expression Regulation
Genes, ras
Histocompatibility Antigens
Methylcholanthrene
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Transfection

Source

Identifiers

PMID: 1995490
DOI: 10.1002/ijc.2910470423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1995490-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas.PMID 1995490Read ↗

Relationship between chemically induced Ha-ras mutation and transformation of BALB/c 3T3 cells: evidence for chemical-specific activation and cell type-specific recruitment of oncogene in transformation.Semantic proximity Read ↗

The H-ras oncogene regulates expression of 70- and 45-kDa cell-surface molecules whose expression correlates with tumor-cell immunogenicity.Semantic proximity Read ↗

Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.Semantic proximity Read ↗

Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.Semantic proximity Read ↗

Ras gene mutation and amplification in human nonmelanoma skin cancers.Semantic proximity Read ↗

Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice.Semantic proximity Read ↗

Identification and quantification of a carcinogen-induced molecular initiation event in cell transformation.Semantic proximity Read ↗

SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.Semantic proximity Read ↗

Low incidence of c-Ha-ras gene mutations in benign and malignant cutaneous lesions from transplant recipients.Semantic proximity Read ↗

Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.Semantic proximity Read ↗

Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors.Semantic proximity Read ↗

Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.