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Article

Impact of the Niemann-Pick c1 Gene Mutation on the Total Cellular Glycomics of CHO Cells.

Journal of proteome research - 4 Aug 2017

Furukawa Jun-Ichi, Soga Minami, Okada Kazue, Yokota Ikuko, Piao Jinhua, Irie Tetsumi, Era Takumi, Shinohara Yasuro

Abstract excerpt

Niemann-Pick disease type C (NPC) is an autosomal recessive lipid storage disorder, and the majority of cases are caused by mutations in the NPC1 gene. In this study, we clarified how a single gene mutation in the NPC1 gene impacts the cellular glycome by analyzing the total glycomic expression profile of Chinese hamster ovary cell mutants defective in the Npc1 gene (Npc1 KO CHO cells). A number of glycomic...

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Source

Identifiers

PMID: 28628327
DOI: 10.1021/acs.jproteome.7b00070

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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