Article
Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non-cirrhotic patients without overt diabetes.
Journal of gastroenterology and hepatology - 1 May 2011
Sumida Yoshio, Kanemasa Kazuyuki, Hara Tasuku, Inada Yutaka, Sakai Kyoko, Imai Shunsuke, Yoshida Naohisa, Yasui Kohichiroh, Itoh Yoshito, Okanoue Takeshi, Yoshikawa Toshikazu
Abstract excerpt
BACKGROUND AND AIM: The hepatitis C virus (HCV) core protein induces hepatic steatosis and glucose intolerance in transgenic mice. The aim of this study was to clarify the impact of mutations in the HCV core region on hepatic steatosis and glucose tolerance in patients with chronic hepatitis C. METHODS: Seventy-four Japanese patients (27 men, 47 women; mean age, 61.9 years) infected with HCV 1b with high viral...
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