Interactions of bambuterol with human serum cholinesterase of the genotypes EuEu (normal), EaEa (atypical) and EuEa.

doi:10.1016/0006-2952(91)90530-i

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Article

Interactions of bambuterol with human serum cholinesterase of the genotypes EuEu (normal), EaEa (atypical) and EuEa.

Biochemical pharmacology - 1 Feb 1991

Tunek A, Hjertberg E, Mogensen J V

Abstract excerpt

Bambuterol, a carbamate ester prodrug of the bronchodilator terbutaline, was tested as inhibitor and substrate of human serum cholinesterases of the genotypes EuEu (the normal enzyme), EaEa (the atypical enzyme) and EuEa. The IC50 for the normal enzyme was 11 +/- 2.2 nM (mean, SD, N = 10) and for...

Topics

Cholinesterases
Genotype
Humans
Isoenzymes
Prodrugs
Terbutaline
Thiocholine

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