Article
Kinetics of the inhibition of human serum cholinesterase phenotypes with the dimethylcarbamate of (2-hydroxy-5-phenylbenzyl)-trimethylammonium bromide (Ro 02-0683).
Biochemical pharmacology - 27 Nov 1991
Prester L, Simeon V
Abstract excerpt
The inhibition of the human serum cholinesterase phenotypes, usual (U), atypical (A) and heterozygous (UA), by the dimethylcarbamate of (2-hydroxy-5-phenylbenzyl)-trimethylammonium bromide (Ro 02-0683), was followed with benzoylcholine, acetyl-, butyryl- and propionyl-thiocholine as substrates. The first-order rate constants were calculated from the linear part of the inhibition curves and were independent of the...
Topics
- Cholinesterase Inhibitors
- Cholinesterases
- Humans
- Isoenzymes
- Kinetics
- Phenotype
- Quaternary Ammonium Compounds