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Article

Interaction of human butyrylcholinesterase variants with bambuterol and terbutaline.

Journal of enzyme inhibition and medicinal chemistry - 1 Apr 2004

Kovarik Zrinka, Simeon-Rudolf Vera

Abstract excerpt

Bambuterol, a dimethylcarbamate, carbamoylates butyrylcholinesterase (BChE; EC 3.1.1.8). The carbamoylated enzyme is not very stable and the final product of the two-step hydrolysis is a bronchodilator drug, terbutaline (1-(3,5-dihydroxyphenyl)-2-t-butylamino-ethanol sulphate). Both bambuterol and terbutaline inhibit BChE, but their affinities differ in human serum BChE variants (U, A, F, K and S) due to their...

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PMID: 15449725
DOI: 10.1080/14756360410001667300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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