Pharmacokinetics of bambuterol in subjects homozygous for the atypical gene for plasma cholinesterase.

doi:10.1046/j.1365-2125.1998.00697.x

Back to search

Article

Pharmacokinetics of bambuterol in subjects homozygous for the atypical gene for plasma cholinesterase.

British journal of clinical pharmacology - 1 May 1998

Bang U, Nyberg L, Rosenborg J, Viby-Mogensen J

Abstract excerpt

AIMS: It has been assumed that both plasma cholinesterase (EC 3.1.1.8) and oxidative enzymes are needed for optimum formation of the bronchodilator terbutaline from its biscarbamate prodrug bambuterol. The present study aimed at investigating the fate of bambuterol in subjects with deficient plas...

Topics

Adult
Area Under Curve
Bronchodilator Agents
Cholinesterases
Debrisoquin
Female
Genotype
Half-Life
Humans
Male
Metabolic Clearance Rate
Middle Aged
Prodrugs
Sympatholytics
Terbutaline

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.