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Article

Pharmacokinetics of bambuterol in subjects homozygous for the atypical gene for plasma cholinesterase.

British journal of clinical pharmacology - 1 May 1998

Bang U, Nyberg L, Rosenborg J, Viby-Mogensen J

Abstract excerpt

AIMS: It has been assumed that both plasma cholinesterase (EC 3.1.1.8) and oxidative enzymes are needed for optimum formation of the bronchodilator terbutaline from its biscarbamate prodrug bambuterol. The present study aimed at investigating the fate of bambuterol in subjects with deficient plasma cholinesterase but with normal oxidative (CYP2D6) capability. METHODS: The pharmacokinetics of bambuterol and...

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Identifiers

PMID: 9643621
DOI: 10.1046/j.1365-2125.1998.00697.x
PMCID: PMC1873551

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