Article
Interconnected feedback loops in the Neurospora circadian system.
Science (New York, N.Y.) - 7 Jul 2000
Lee K, Loros J J, Dunlap J C
Abstract excerpt
In Neurospora crassa, white collar 1 (WC-1), a transcriptional activator and positive clock element, is rhythmically expressed from a nonrhythmic steady-state pool of wc-1 transcript, consistent with posttranscriptional regulation of rhythmicity. Mutations in frq influence both the level and periodicity of WC-1 expression, and driven FRQ expression not only depresses its own endogenous levels, but positively...
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