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Article

Interaction of heparins and dextran sulfates with a mesoscopic protein nanopore.

Biophysical journal - 2 Dec 2009

Teixeira Luciana R, Merzlyak Petr G, Valeva Angela, Krasilnikov Oleg V

Abstract excerpt

A mechanism of how polyanions influence the channel formed by Staphylococcus aureus alpha-hemolysin is described. We demonstrate that the probability of several types of polyanions to block the ion channel depends on the presence of divalent cations and the polyanion molecular weight and concentration. For heparins, a 10-fold increase in molecular weight decreases the half-maximal inhibitory concentration,...

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Identifiers

PMID: 19948118
DOI: 10.1016/j.bpj.2009.09.019
PMCID: PMC2784562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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