Article
Nanopore force spectroscopy on DNA duplexes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Jetha Nahid N, Wiggin Matthew, Marziali Andre
Abstract excerpt
Force spectroscopy can be applied using nanopores to study charged molecules such as nucleic acids. This technique can be used to study the binding energy of a DNA duplex by threading an anchored single-stranded DNA (ssDNA) probe molecule through a nanopore (having a diameter large enough to acco...
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