Article
Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases.
FEBS letters - 4 Jan 2010
Wakasugi Keisuke
Abstract excerpt
Tryptophanyl-tRNA synthetases (TrpRSs) catalyze the aminoacylation of tRNA(Trp). Previously, I demonstrated that Zn(2+)-depleted human TrpRS is enzymatically inactive and that binding of Zn(2+) or heme to human TrpRS stimulates its aminoacylation activity. In the present study, bovine and mouse TrpRSs were found to be constitutively active regardless of the presence of Zn(2+) or ferriprotoporphyrin IX chloride....
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