Article

Both ATP and Mg <sup>2+</sup> are Required for High-Affinity Binding of Indolmycin to Human Mitochondrial Tryptophanyl-tRNA Synthetase

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Eukaryotes have distinct nuclear genes for tryptophanyl-tRNA synthetase (TrpRS). Human mitochondrial (H mt ) TrpRS (also WARS2) shares only 14% sequence identity with human cytoplasmic (H c )TrpRS, but 41% with Bacillus stearothermophilus (Bs)TrpRS. Tryptophan binding to BsTrpRS is largely promoted by hydrophobic interactions and recognition of the indole nitrogen by side chains of Met 129 a...

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Literature Corpus work: 6698f4a3-b765-59b6-8067-1e97429c0233
DOI: 10.64898/2026.03.23.713518

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