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Article

Amino acid discrimination by a highly differentiated metal center of an aminoacyl-tRNA synthetase.

Biochemistry - 23 Sept 2003

Zhang Chun-Mei, Perona John J, Hou Ya-Ming

Abstract excerpt

Escherichia coli cysteinyl-tRNA synthetase (CysRS) achieves high amino acid specificity without the need for an editing reaction. Crystallographic and spectroscopic studies have previously demonstrated that a major determinant of the specificity is an active site zinc ion that recognizes the substrate cysteine through a strong zinc-thiolate interaction. The active site cleft of CysRS is composed of highly or...

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PMID: 12974627
DOI: 10.1021/bi034812u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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