Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target

26 Apr 2021

Abstract excerpt

during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA modifications and cancer
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33926067
DOI: 10.3390/ijms22094523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tryptophanyl-tRNA Synthetase as a Potential Therapeutic TargetPMID 33926067Read ↗

Aminoacyl-tRNA synthetases: Structure, function, and drug discovery.Semantic proximity Read ↗

Aminoacyl tRNA synthetases and their connections to disease.Semantic proximity Read ↗

Aminoacyl-tRNA synthetases in medicine and disease.Semantic proximity Read ↗

Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity.Semantic proximity Read ↗

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and BeyondSemantic proximity Read ↗

Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.Semantic proximity Read ↗

Ushering in the era of tRNA medicines.Semantic proximity Read ↗

Recent Development of Aminoacyl-tRNA Synthetase Inhibitors for Human Diseases: A Future PerspectiveSemantic proximity Read ↗

Transfer RNA and small molecule therapeutics for aminoacyl-tRNA synthetase diseases.Semantic proximity Read ↗

tRNA therapeutics for genetic diseases.Semantic proximity Read ↗

Human aminoacyl-tRNA synthetases in diseases of the nervous system.Semantic proximity Read ↗

The role of aminoacyl-tRNA synthetases in genetic diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.