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Article

Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin.

Journal of pharmacokinetics and pharmacodynamics - 1 Feb 2010

Yuen Eunice, Gueorguieva Ivelina, Wise Stephen, Soon Danny, Aarons Leon

Abstract excerpt

Ethnic differences in warfarin maintenance doses have been documented amongst the three major Asian ethnic groups (Chinese, Malay and Indian) in Singapore. Studies have shown that cytochrome P450 2C9 (CYP2C9) polymorphisms alone did not entirely account for these differences. Recent reports suggest that VKORC1 (subunit of vitamin K epoxide reductase) haplotypes are more predictive of warfarin response. Population...

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Source

Identifiers

PMID: 19941044
DOI: 10.1007/s10928-009-9138-4

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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