Article
Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo.
The Journal of biological chemistry - 22 Jan 2010
Jedidi Iness, Zhang Fan, Qiu Hongfang, Stahl Stephen J, Palmer Ira, Kaufman Joshua D, Nadaud Philippe S, Mukherjee Sujoy, Wingfield Paul T, Jaroniec Christopher P, Hinnebusch Alan G
Abstract excerpt
Mediator is a multisubunit coactivator required for initiation by RNA polymerase II. The Mediator tail subdomain, containing Med15/Gal11, is a target of the activator Gcn4 in vivo, critical for recruitment of native Mediator or the Mediator tail subdomain present in sin4Delta cells. Although several Gal11 segments were previously shown to bind Gcn4 in vitro, the importance of these interactions for recruitment of...
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