Article
A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
AIDS (London, England) - 2 Jan 2010
Yoon Woohyun, Ma Ben-Jiang, Fellay Jacques, Huang Wei, Xia Shi-Mao, Zhang Ruijun, Shianna Kevin V, Liao Hua-Xin, Haynes Barton F, Goldstein David B
Abstract excerpt
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was obser...
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