Article
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
Human molecular genetics - 1 Feb 2010
Perry John R B, Weedon Michael N, Langenberg Claudia, Jackson Anne U, Lyssenko Valeriya, Sparsø Thomas, Thorleifsson Gudmar, Grallert Harald, Ferrucci Luigi, Maggio Marcello, Paolisso Giuseppe, Walker Mark, Palmer Colin N A, Payne Felicity, Young Elizabeth, Herder Christian, Narisu Narisu, Morken Mario A, Bonnycastle Lori L, Owen Katharine R, Shields Beverley, Knight Beatrice, Bennett Amanda, Groves Christopher J, Ruokonen Aimo, Jarvelin Marjo Riitta, Pearson Ewan, Pascoe Laura, Ferrannini Ele, Bornstein Stefan R, Stringham Heather M, Scott Laura J, Kuusisto Johanna, Nilsson Peter, Neptin Malin, Gjesing Anette P, Pisinger Charlotta, Lauritzen Torsten, Sandbaek Annelli, Sampson Mike, Zeggini Ele, Lindgren Cecilia M, Steinthorsdottir Valgerdur, Thorsteinsdottir Unnur, Hansen Torben, Schwarz Peter, Illig Thomas, Laakso Markku, Stefansson Kari, Morris Andrew D, Groop Leif, Pedersen Oluf, Boehnke Michael, Barroso Inês, Wareham Nicholas J, Hattersley Andrew T, McCarthy Mark I, Frayling Timothy M
Abstract excerpt
Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial. Genetic studies can help dissect causal directions of epidemiological associations because genotypes are much less likely to be confounded, biased or influenced by disease processes....
Topics
- Adult
- Aged
- Case-Control Studies
- Diabetes Mellitus, Type 2