Article
Inherited variants in MYH are unlikely to contribute to the risk of lung carcinoma.
Human genetics - 1 Jan 2004
Al-Tassan Nada, Eisen Tim, Maynard Julie, Bridle Helen, Shah Bindiya, Fleischmann Christina, Sampson Julian R, Cheadle Jeremy P, Houlston Richard S
Abstract excerpt
The base excision repair gene MYH protects against damage to DNA from reactive oxygen species, which are commonly found in cigarette smoke. Inherited mutations in MYH predispose to colorectal adenomas and carcinomas that show a characteristic pattern of somatic G:C-->T:A mutations in the APC gene. A similar pattern of somatic mutations in the TP53 gene is reported in smoking-related lung cancers. We therefore...
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