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Article

Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Nov 2017

Metzger Michael W, Walser Sandra M, Dedic Nina, Aprile-Garcia Fernando, Jakubcakova Vladimira, Adamczyk Marek, Webb Katharine J, Uhr Manfred, Refojo Damian, Schmidt Mathias V, Friess Elisabeth, Steiger Axel, Kimura Mayumi, Chen Alon, Holsboer Florian, Arzt Eduardo, Wurst Wolfgang, Deussing Jan M

Abstract excerpt

A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders. The P2X7R-Gln460Arg variant per se is not compromised in its function. However, heterologous expression of P2X7R-Gln460Arg together with wild-type P2X7R has recently been demonstrated to impair receptor function. Here we...

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Identifiers

PMID: 29079688
DOI: 10.1523/JNEUROSCI.3487-16.2017
PMCID: PMC6705750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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