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Article

Smooth muscle phenotypic modulation is an early event in aortic aneurysms.

The Journal of thoracic and cardiovascular surgery - 1 Dec 2009

Ailawadi Gorav, Moehle Christopher W, Pei Hong, Walton Sandra P, Yang Zequan, Kron Irving L, Lau Christine L, Owens Gary K

Abstract excerpt

OBJECTIVES: Vascular smooth muscle cells can undergo profound changes in phenotype, defined by coordinated repression of smooth muscle cell marker genes and production of matrix metalloproteinases in response to injury. However, little is known of the role of smooth muscle cells in aortic aneurysms. We hypothesized that smooth muscle cells undergo phenotypic modulation early in the development of aortic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19931668
DOI: 10.1016/j.jtcvs.2009.07.075
PMCID: PMC2956879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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