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Article

Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.

Journal of the Royal Society, Interface - 1 May 2017

Bellini C, Bersi M R, Caulk A W, Ferruzzi J, Milewicz D M, Ramirez F, Rifkin D B, Tellides G, Yanagisawa H, Humphrey J D

Abstract excerpt

Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals alike. They frequently associate with genetic mutations and are characterized by reduced elastic fibre integrity, dysfunctional smooth muscle cells, improperly remodelled collagen and pooled mucoid material. There is a pressing need to understand better the compromised structural integrity of the aorta that results from...

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Identifiers

PMID: 28490606
DOI: 10.1098/rsif.2016.1036
PMCID: PMC5454287

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