Article
Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm.
Journal of translational medicine - 12 Sept 2013
Riches Kirsten, Angelini Timothy G, Mudhar Gurprit S, Kaye Jean, Clark Emily, Bailey Marc A, Sohrabi Soroush, Korossis Sotirios, Walker Peter G, Scott D Julian A, Porter Karen E
Abstract excerpt
BACKGROUND: Vascular smooth muscle cells (SMC) are central to arterial structure and function yet their involvement in the progression of abdominal aortic aneurysm (AAA) disease is not well studied. The progressive and silent nature of AAA in man essentially restricts research to the use of "end-stage" tissue recovered during surgical repair. This study aimed to generate an ex vivo model of AAA using...
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