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Article

Conserved determinants of lentiviral genome dimerization.

Retrovirology - 29 Sept 2015

Tran Thao, Liu Yuanyuan, Marchant Jan, Monti Sarah, Seu Michelle, Zaki Jessica, Yang Ae Lim, Bohn Jennifer, Ramakrishnan Venkateswaran, Singh Rashmi, Hernandez Mateo, Vega Alexander, Summers Michael F

Abstract excerpt

BACKGROUND: Retroviruses selectively package two copies of their unspliced genomes by what appears to be a dimerization-dependent RNA packaging mechanism. Dimerization of human immunodeficiency virus Type-1 (HIV-1) genomes is initiated by "kissing" interactions between GC-rich palindromic loop residues of a conserved hairpin (DIS), and is indirectly promoted by long-range base pairing between residues overlapping...

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Identifiers

PMID: 26420212
DOI: 10.1186/s12977-015-0209-x
PMCID: PMC4588261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conserved determinants of lentiviral genome dimerization.PMID 26420212Read ↗

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