Article

Towards optimising HIV-1 derived lentiviral vectors through structure informed genome modifications

2020-01-01

Abstract excerpt

Lentiviral vectors are being successfully used as therapeutic agents in a series of clinical applications of gene therapy, genome editing and cancer immunotherapy. 3rd generation HIV-1 derived lentiviral vectors are produced from 4 independent plasmids. Here, I focus on the transfer vector that contains the therapeutic gene and the cis-acting elements that drive its expression including the packaging signal (psi)....

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Literature Corpus work: 595aa02c-5de9-5784-b340-597ef3b266d6
DOI: 10.17863/cam.51498

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