Toll‐like receptor 4 signalling through MyD88 is essential to control <i>Salmonella enterica</i> serovar Typhimurium infection, but not for the initiation of bacterial clearance

Abstract excerpt

Toll-like receptor-4 (TLR4) is important in protection against lethal Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Control of the early stages of sublethal S. Typhimurium infection in mice depends on TLR4-dependent activation of macrophages and natural killer (NK) cells to drive an inflammatory response. TLR4 signals through the adapter proteins Mal/MyD88 and TRIF-related adaptor molecule...

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