<i>Salmonella typhimurium</i> Persists within Macrophages in the Mesenteric Lymph Nodes of Chronically Infected <i>Nramp1</i> + <i>/</i> + Mice and Can Be Reactivated by IFNγ Neutralization

Abstract excerpt

Host-adapted strains of Salmonella are capable of establishing a persistent infection in their host often in the absence of clinical disease. The mouse model of Salmonella infection has primarily been used as a model for the acute systemic disease. Therefore, the sites of long-term S. typhimurium persistence in the mouse are not known nor are the mechanisms of persistent infection clearly understood. Here, we...

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