The streptomycin mouse model for <i>Salmonella</i> diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response

Abstract excerpt

The mammalian intestine is colonized by a dense microbial community, the microbiota. Homeostatic and symbiotic interactions facilitate the peaceful co-existence between the microbiota and the host, and inhibit colonization by most incoming pathogens ('colonization resistance'). However, if pathogenic intruders overcome colonization resistance, a fierce, innate inflammatory defense can be mounted within hours, the...

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