Article
Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.
Inflammatory bowel diseases - 1 Nov 2013
Salk Jesse J, Bansal Aasthaa, Lai Lisa A, Crispin David A, Ussakli Cigdem H, Horwitz Marshall S, Bronner Mary P, Brentnall Teresa A, Loeb Lawrence A, Rabinovitch Peter S, Risques Rosa Ana
Abstract excerpt
BACKGROUND: Patients with ulcerative colitis (UC) are at risk of developing colorectal cancer. We have previously reported that cancer progression is associated with the presence of clonal expansions and shorter telomeres in nondysplastic mucosa. We sought to validate these findings in an independent case-control study. METHODS: This study included 33 patients with UC: 14 progressors (patients with high-grade...
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