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Article

Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays.

BMC genomics - 3 Jul 2008

Rennie Catriona, Noyes Harry A, Kemp Stephen J, Hulme Helen, Brass Andy, Hoyle David C

Abstract excerpt

BACKGROUND: Microarrays are an important and widely used tool. Applications include capturing genomic DNA for high-throughput sequencing in addition to the traditional monitoring of gene expression and identifying DNA copy number variations. Sequence mismatches between probe and target strands are known to affect the stability of the probe-target duplex, and hence the strength of the observed signals from...

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PMID: 18598341
DOI: 10.1186/1471-2164-9-317
PMCID: PMC2475537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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