Article
Analysis of context-dependent errors for illumina sequencing.
Journal of bioinformatics and computational biology - 1 Apr 2012
Abnizova Irina, Leonard Steven, Skelly Tom, Brown Andy, Jackson David, Gourtovaia Marina, Qi Guoying, Te Boekhorst Rene, Faruque Nadeem, Lewis Kevin, Cox Tony
Abstract excerpt
The new generation of short-read sequencing technologies requires reliable measures of data quality. Such measures are especially important for variant calling. However, in the particular case of SNP calling, a great number of false-positive SNPs may be obtained. One needs to distinguish putative SNPs from sequencing or other errors. We found that not only the probability of sequencing errors (i.e. the quality...
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