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Article

Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop.

Channels (Austin, Tex.) - 1 Jan 2000

Rosenhouse-Dantsker Avia, Leal-Pinto Edgar, Logothetis Diomedes E, Levitan Irena

Abstract excerpt

Kir channels are important in setting the resting membrane potential and modulating membrane excitability. A common feature of Kir2 channels and several other ion channels that has emerged in recent years is that they are regulated by cholesterol, a major lipid component of the plasma membrane whose excess is associated with multiple pathological conditions. Yet, the mechanism by which cholesterol affects channel...

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Identifiers

PMID: 19923917
DOI: 10.4161/chan.4.1.10366
PMCID: PMC2907253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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